Introduction of Excipients into Tablets

Lactose, Starch & PVP are very common Excipients being used for Conventional Tablet binding & Granulation in Pharmaceutical Segment. Each specific individual ingredient plays an important role in tablet compression and granulation process. Simultaneously these excipients have advantages as well as disadvantages when they are added individually. Using lactose in tablet compressions & granulations have always a question of moisture and poor flowability due to its physical & chemical characteristics.

While using Starch & PVP as lubricant or binder in compression and granulation are again a bit worry for the formulators. In wet granulation (involving wet massing) using Starch paste can have adverse effect on water sensitive drugs and also it needs longer drying time, increasing extended time process & cost for production. Mixing and milling of the hygroscopic diluents, binder & disintegrant is a huge task for the formulators as it is a very tedious, lengthy & time consuming process. Due to its irregular shape, broad particle size distribution and poor flow ability questions like consistency, uniformity & quality products are still unresolved!

Granla LS-G

What is Granlak LS-G & Why to use in Tablet compression and Granulation ?

Through the years of the research and experiments in the excipients in tablet direct compression and automatic capsule filling, we are able to develop Granlak LS-G at Mingtai Chemical Co. Taiwan. GRANLAK LS-G is a Grace for the formulators in the pharmaceutical world as it's ready and easy to use excipient. It helps in producing cost effective formulations to match the entire requirement you expect……

Granlak LS-G is our one of most ready to use excipients made by our technology expert from Lactose, Starch & PVP. While Granlak LS-G is used in direct compression, granulations, formulation steps and time is saved by almost 70% that also by improving consistency as well as quality and off-course cost effectiveness.

Comparision of Dry Granulation & Wet Granulation versus Granlak LS-G :-

We are presenting you the chart of Direct compression, Wet compression and Granlak LS-G compression for your easy reference.

Granlak LS-G Compression	Dry Granulation	Wet Granulation
Mixing / Blending of API & Granlak LS-G	Mixing / Blending of API and excipients	Mixing / Blending of API and excipients
Compression	Milling	Preparation of binder solution
Mixing of Lubricant & Disintegrant (If required)	Compression in to Slugs	Massing of binder soln of step 2 with powder mixture of step 1
Final Product	Size reduction of Slugs	Wet screening of damp mass
	Screening of Slugs	Drying of wet granules
	Mixing of granules with pharmaceutical aids	Resifting of dried granules through a suitable sieve
	Mixing with lubricant & disintegrating agent	Mixing of dried granules with lubricant & disintegrating agent
	Final Product	Blending with pharmaceutical aids
		Final Product

How GRANLAK LS-G is beneficial in formulation process :-

	GRANLAK LS-G is a ready to use formula which can be used directly in Dry granulations to minimize the production time and cost.
	GRANLAK LS-G is ready to use excipient which minimizes almost three steps in Dry granulations as shown in the comparision chart.
	For uniform mixing & better results the coarse of drug ingredients are pulverized to 80-100 mesh before mixing with Granlak LS-G
	For quick dispersible tablets, mixing with disintegrant such as Disolcel (Croscarmellose sodium/CCS), DST (Sodium Starch Glycolate/SSG), Comprecel (MCC) can be done for good results.
	Conventional tabletting machine, single punch, rotary punch or direct punch tabletting machines are well served for this purpose.
	Granlak LS-G is Used as ready excipients for direct compression & Capsule filling.
	Granlak LS-G is Used as ready excipients for granules and powder formulations.
	Granlak LS-G is Ready to use formula for Lactose & Starch users. (Dummy Placebo)

Granla LS-G Features

	Granlak LS-G is produced from renowned world class excipients to help in achieving consistent results.
	Granlak LS-G is ready to use excipient which minimizes the formulation process in three steps as against 6-9 steps in conventional method.
	GRANLAK LS-G is a ready to use formula which can be used directly in Dry granulations to minimize the production time and cost.
	Process ingredients are meeting with USP/NF, EP and JP pharmacopeial standards.
	Granlak LS-G is Extremely low moisture content hence has good flowability.
	Since Granlak LS-G is non toxic no negative interaction occurs with most of drugs and APIs.
	Granlak LS-G is Free from OVI impurities.
	Granlak LS-G is Complying with Microbial limits.
	Since Granlak LS-G is having porous granules that help variation free formulations during process.
	Granlak LS-G has good free flowing properties that help in reducing capping and improving compressibility.