Hydrophilic Matrix Systems

Hydrophilic matrix systems designed with water-soluble polymers, such as Hypromellose, were first introduced in the early 1970’s. Since then, development work has concentrated on controlled release technology, and many types of advanced polymers and techniques have become available.

The hydrophilic matrix system is the simplest sustained release technology for oral dosage forms, consisting essentially of a drug and a water soluble, highly viscous polymer. It does not require any other excipient. Hydrocel HPMC plays a major role in Tablets for formulations that are Sustained Release, Controlled Release, Extended Release & for Coating of Tablets and Pellets

In the recent years, advances in this hydrophilic matrix system have allowed more controllable and reproducible drug release by controlling the chemical and physical properties of the polymer. Hydrocel-CR (Hypromellose) is especially suitable for this application, and provides a genuine consistency in the final products.

The matrix system is advantageous in many ways for this application

• It is very simple and easy to establish a formulation.
• The tablet is completely dissolved and thus achieves good bioavailability.
• It is easy to control the dissolution profile by selecting a specific grade.
• The matrix system is an economical method for obtaining controlled release products.

Hydrocel-CR, USP Hypromellose (HPMC), is designed for a hydrophilic matrix agent having tighter specifications, which is especially suitable for wet granulation and direct compression application. Consistency in every batch is of the highest level, as Hydrocel HPMC is developed with stringent in-house specifications with a narrow limit.

Pioma Chemicals is a supplier of Hydrocel HPMC in India. Hydrocel-CR® HPMC is an alternative to Anycoat®, Pharmacoat® and Methocel™ HPMC